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Nat Rev Cancer 21(1):1832 Veith A, Henderson K et al (2019) Therapeutic strategies for enhancing angiogenesis in wound healing

We tailor linker structures based on client drug structure, target characteristics, and release requirementsincluding length, spatial configuration, hydrophobicity/hydrophilicity, and reactive groupsto achieve optimal efficacy and stability balance

F., & Nezavibatko, V

In the VitroGel hydrogels, the cells exhibited substantially more spheroid clustering, even at the lower dilutions (Fig 1B-E)

These findings suggest that despite bearing a reactive electrophile, C1-27 did not bind to cellular proteins indiscriminately but appeared to exhibit certain degree of selectivity in target binding