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2-adrenoceptor agonists Clonidine gel: A randomized, double-blind, placebo-controlled, parallel-group, multicenter trial showed that topical clonidine gel significantly reduced the level of pain in subjects with DN in whom there are functional (and possibly sensitized) nociceptors in the affected skin

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If you have active malignancy, a history of cancer, or elevated cancer risk, introducing a pro-angiogenic compound is mechanistically dangerous

Oct 2021;48(5):803-808

Lancet 388 , 28732884 (2016)