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One study (Schlmerich et al ., Reference Schlmerich, Fellermann, Seibold, Rogler, Langhorst, Howaldt, Novacek, Petersen, Bachmann and Matthes2017) which investigated different doses of TSO, ranging from TSO 250 to TSO 7500, did suggest that higher doses may have greater efficacy

After 8 weeks of continuous dosing, the number of bowel movements was significantly reduced, the fecal calprotectin content was reduced, and the symptoms improved significantly