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PloS One (2012) 7(9):e46364

Vitamin B12 treatment strongly affects the brain metabolome and transcriptome, and partially compensates for the effects of Tbx1 haploinsufficiency Given the ability of vB12 prenatal treatment to rescue diverse phenotypes caused by Tbx1 haploinsufficiency (13, 14, 15), we asked whether this occurs through metabolic mechanisms that are transcriptionally regulated by TBX1 or by rebalancing the brain metabolic profile of Tbx1 +/ mice

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Both peptides ship lyophilized and are reconstituted before use, most commonly with bacteriostatic water, and both should be stored cold and protected from repeated freeze-thaw cycles

Patients would require either two (2) devices (for a 56 mg dose) or three (3) devices (for an 84 mg dose) per treatment