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Addressing these questions will significantly advance our understanding of Mn-related pathophysiology and may lead to new therapeutic opportunities

Resulting protein solutions were subjected to filter-aided sample preparation (FASP) as described elsewhere 122 covering proteins alkylation (100 mM iodoacetamide (IAA) for 20 min in dark at laboratory temperature) and proteins digestion using 0.75 g of trypsin (sequencing grade

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Organic pollutants The association between organic inhaled pollutants and neurological diseases is supported by substantial clinical evidence

The -lactam antibiotic ceftriaxone (Cef) induces EAAT2 in cultured murine spinal cord slices (Rothstein et al., 2005) and in neuron/astrocyte co-cultures (Lewerenz et al., 2009)