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L-type amino acid transport and cancer: Targeting the mTORC1 pathway to inhibit neoplasia

About this article Cite this article Bioletto, F., Varaldo, E., Gasco, V

doi: 10.1200/JCO.2021.39.15_suppl.1050 249 AndreanoKJWardellSEBakerJGDesautelsTKBaldiRChaoCAet al

PERKdependent signals also lead to the activation of the transcription factor NFE2related factor 2 (Nrf2

injections of 100 nmol kg 1 PYY analogue ( n = 7 mice and n = 6 cages), 100 nmol kg 1 PYYMK-801 ( n = 7 mice and n = 4 cages), 100 nmol kg 1 GLP-1MK-801 ( n = 7 mice and n = 5 cages) or vehicle (isotonic saline, n = 7 mice and n = 4 cages) for 6 days