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Prior efforts have reported markedly decreased snRNP assembly activity and reduced snRNA levels in SMN-deficient cells 22,23,24,25 , SMA mice 24,25,26,27 and SMA patient tissues 22,27 , thereby producing broadly misregulated RNA splicing 24,25

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Notably, LDs cooperate with peroxisomes to regulate PUFA metabolism

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They feel like their metabolism has slowed down