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When mitochondria lack sufficient oxygen, they undergo mitophagy, a form of mitochondrial decay that is an early sign of organ degeneration and chronic disease

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Zhu, Z., Xu, W

Importantly, this junction also represents the entry point into the pentose phosphate pathway (PPP), which shunts glucose away from energy production and instead generates NADPH, an essential cofactor required for glutathione synthesis and redox homeostasis

Treating seven to nine hours as part of the protocol rather than an afterthought is one of the highest-return habits on the list, and it costs nothing