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Hepatotoxicity Several oral agents, especially tyrosine kinase inhibitors (TKIs) such as pazopanib, lapatinib, and sunitinib , are associated with hepatotoxicity , which can range from mild transaminase elevation to fulminant hepatic failure

Apply sunscreen generously to all exposed areas of the skin, including the face, neck, and dcolletage, and reapply every two hours when exposed to sunlight

Apply broad-spectrum sunscreen SPF 50 daily to prevent re-tanning 2

This review highlights recent advances in the use of various natural compounds, including flavonoids, phenolic compounds, saponins, terpenoids, alkaloids and coumarins, with a particular focus on how they modulate the mitogen-activated protein kinase (MAPK) signaling pathway

In addition, ROS generated in mitochondria and the endoplasmic reticulum also contribute to the development of hypertension (157, 158)