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The accumulation of ROS is responsible for lipid bilayer damage which causes mitochondrial swelling (Bodaghi-Namileh et al., 2018)

PARP-1 hyperactivation depletes cytosolic NAD + , a central redox cofactor essential for glycolysis and TCA cycle function, precipitating bioenergetic failure

At concentrations that are high relative to the K m , the elimination rate is almost independent of concentrationa state of pseudo-zero order elimination

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