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Significantly, skeletal muscle serves as a crucial target for managing hyperglycemia, accounting for roughly 80% of postprandial insulin-mediated glucose absorption and is essential for maintaining glucose equilibrium (Nia et al., 2002

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Although quiescent under normal conditions, PSCs are activated after pancreatic injury and transform into a myofibroblast-like -smooth muscle actin (SMA)-positive cell type that actively proliferates, produces extracellular matrix (ECM) and secretes growth factors (1215)

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There are also studies confirming that melatonin supplementation can prevent or delay the deterioration of immune system function that accompanies aging and may restore it to a youthful state (149)