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Introduction Cancers are initiated by genetic preconditions and epigenetic alterations, accompanied by various mechanisms, most of which are still unclear (Bach and Lee, Hepatocyte growth factor (HGF)/c-mesenchymal-epithelial transition factor (c-Met) axis is an essential mediation axis that regulates cellular biological events including cell proliferation, migration and morphogenesis and tumor biological processes such as angiogenesis and drug resistance (Ebens et al., 2018)

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Edward Rubin, MD board-certified in Pain Medicine and Anesthesiology, with fellowship training at Cornell, Columbia, Hospital for Special Surgery, and Memorial Sloan Kettering

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First, the complex appears to act as a copper transporter, delivering ionic copper to cutaneous cells where it may activate copper-dependent enzymes involved in extracellular-matrix remodeling and angiogenesis

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The mechanisms most cited in the literature are promotion of angiogenesis (new blood-vessel formation, linked to VEGFR2 signaling), modulation of growth-factor and nitric-oxide pathways, and interaction with the gut-brain axis

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In preclinical models, Dihexa has shown the ability to increase synaptic markers like synaptophysin, improve neuronal counts in the hippocampus, and restore spatial memory and learning capacity in cognitively impaired animals

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