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Upon inflammation, as IFN- can activate IDO (209), there is an immunoregulatory induction of IDO activity, and therefore a depletion of trp available for serotonin synthesis

These downstream effects have contributed to clinical interest in GH secretagogue protocols within regenerative medicine contexts

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Excessive production of reactive species leads to various pathological diseases such as ulcerogenic, depression, cardiovascular disorders, and rheumatoid arthritis