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It inhibits NNMT, an enzyme that methylates nicotinamide (a precursor to NAD+)

AOD-9604 can be administered via subcutaneous injection or orally, depending on the formulation available

It is indicated for the treatment of Polyneuropathy of any origin such as Diabetic, Alcoholic or Toxic neuropathies, Neuritis, Neuralgia, Cervical Syndrome, Shoulder-arm syndrome, Lumbago, Sciatica, Mayalgia, Herpes Zoster, Trigeminal Neuralgia, Supportive treatment in facial paresis Dosage & Administration: Tablet: 1 to 3 tablets daily or as directed by the physician

Muscle Function: Beyond fat cells, recent studies indicate that NNMT inhibition may rejuvenate aged muscle stem cells (satellite cells), promoting better regeneration and contractile force in older models

doi: 10.3899/jrheum.130367 6 FukudaK.StrausS