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Mice deprived of leucine had increased HPA axis activation via CRH expression (337)

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This was supported by the upregulation of adipogenic markers FABP4 and PPAR, with respective increases in mRNA levels of 3.0- and 2.2-fold in comparison to undifferentiated cells [1]

Despite the well-known regulatory pathways of ferroptosis, such as the GSH/GPX4 regulatory pathway, the FSP1/CoQ10 pathway, and iron metabolism and lipid metabolism, whether there are other regulatory mechanisms is unclear