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Other symptoms and signs commonly include abdominal pain in 80%, headache or migraine in about 40%, and nearly all children have pallor and fatigue

Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial oxidation of fatty acids to prevent lethal accumulation of longchain acylcarnitines in the mouse liver

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The muscle symptoms seen in children in whom muscle involvement is part of a systemic illness are predominantly hypotonia and generalized muscle weakness

Water helps maintain bodily functions and normal body temperature, making hydration essential