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Given that 70% of Mel and 85% of insulin-stimulated glucose disposal enters the skeletal muscle, the enhancement of insulin sensitivity and glucose balance by MOTS-c may be mediated in this tissue

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However, the density of 5-HT2A receptors within the RSG is much lower which theoretically would omit this brain region as an area of interest

doi: 10.1128/MCB.00166-09 263 FeldmanDEChauhanVKoongAC