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In CRC, miR-21 is one of the most prominent oncogenic miRNAs [111]

Xu J, Guo H, Xing Z, Zhang W, He J, Cheng J, et al

IM administration may provide the most robust response in clinical scenarios requiring rapid or substantial metabolic correction

Vitamin B12, like other B vitamins, is important for protein metabolism, aids in the formation of red blood cells and maintenance of the central nervous system

Also, orthotopic implantation into the cerebellum has been associated with improved engraftment efficiency, particularly for tumors with lower proliferative potential, compared to subcutaneous approaches (127, 128)