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Only two drugs are currently approved by the US Food and Drug Administration for ALS treatment, including riluzole, a neuroprotective glutamate antagonist that extends the survival rate over 2-3 months, and edaravone, an antioxidant that delays ALS progression only beneficial in a subset of patients with early-stage ALS[811]

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It is also a heterogeneous disorder, including a various blend of positive symptoms, NS and cognitive impairment

The findings are consistent with what we would expect given the low volume of cases in the NonCC subgroups compared to the volume of cases in the CC subgroups for these MS-DRGs

Although an elevated activity was observed in groups 2 and 3 on day 30, it was still within the control range (Figure 5A)