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Blue light irradiation leads to dysfunction of lysosomes, decreased ability of lysosome phagocytosis and autophagy, accumulation of lipofuscin in cells, disruption of epithelial barrier, and ultimately resulting in cell apoptosis

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The invariant cis -Pro residue is located in the loop region before 3 and is thought to be implicated in the maintenance of the enzyme fold rather than playing a role in the enzymatic reaction (Figure 3A) (Allocati et al., cis -proline is hydrogen-bonded to the backbone of CysGS (cysteine residue of glutathione) (Figure 3A)

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