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The above combinatorial methods synergize tumor ablation, significantly strengthening the effectiveness of GBM treatment [703]

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Finally, inadequate DNA repair and spindle defects lead to mitotic catastrophe, forming multinucleated or giant cells that eventually undergo apoptosis, necrosis, or irreversible cell cycle arrest, leading to the loss of epithelial and crypt cells in rapidly proliferating tissues like the gastrointestinal tract and skin, thus amplifying radiation-induced damage [48]