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Numerous agents targeting the JAKs-STAT1/5, JAKs-STAT3/6, TLR4-NF-B, MAPK, PI3K-AKT-mTOR, AMPK-PPAR and Nrf2-HO-1 pathways have been shown to induce M2 macrophage polarization and/or inhibit M1 macrophage polarization (178, 179), paving the way for the development of novel therapeutic strategies targeting macrophage functions specific to CKD and associated pathologies

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The higher the p K a of the precursor, the more rapid is its conversion to the active molecule, and this can be expected to be true with both Brnsted and Lewis acids