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Such studies may shed light on the underlying causes of melanocyte destruction and pave the way for interventions that prevent melanocyte degeneration and allow for long-lasting repigmentation, an important therapeutic target in vitiligo treatment

Frentzas et al

Finally, GCR1/2 and their downstream target, LFS, may form a negative feedback loop that has been shown in many biological systems to maintain the homoeostasis of the signalling or regulation

187 The metanalysis involved a total of 11 studies comprising 1,021 participants: 685 received an SPRM (MFP, UPA, and ASP)