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To elucidate the therapeutic potential of targeting VEGF signaling in EAE, mice were treated with the selective VEGF receptor inhibitor semaxinib (Roscoe and Welsh 2009)

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Reported Mild Effects: Temporary injection site redness Slight drowsiness (when dosed in evening) Vivid dreams or altered sleep patterns Mild headaches during initial days Management Strategies: Rotate injection sites regularly Reduce dosage if effects seem excessive Maintain hydration throughout protocol Consider timing adjustments for sleep-related effects When to Modify or Discontinue Certain situations warrant protocol modifications or discontinuation

Environ Exp Bot 62:153159 Anderson JW, Foyer CH, Walker DA (1983) Light-dependent reduction of dehydroascorbate and uptake of exogenous ascorbate by spinach chloroplasts