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The sham group showed basal IkB- cytosolic expression (Figure 6C) and poor nuclear NF-kB p-65 levels (Figure 6D)

doi: 10.1016/j.hoc.2022.02.001 3 FanAWangBWangXNieYFanDZhaoXet al

Knoepfler also notes that the same substance that's helpful at one dose might be ineffective or even harmful at another dose

This aspect is, indeed still mysterious even if a protein with CAT feature has been described in the nuclear extract from HEK293 cells (Madiraju et al., 2009)