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The uncontrolled induction of iNOS by IFNy and the consequent increased production of NO can result in a greater oxidative load and cause nitrosative stress, possibly due to resistance to toxicity of glial cell cultures to high GSH levels in the microglia, and to up-regulation of Mn-SOD in the mitochondria in the course of the induction of i-NOS

At room temperature (2025C), that rate increases to 1015% per day

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