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Expression and purification of recombinant methyltransferase proteins NSD1(SET) (amino acids 18532093, NCBI sequence: NC_000005.10), NSD2(SET) (amino acids 9581365, NCBI sequence: NC_000004.12), NSD3(SET) (amino acids 10211320, NCBI sequence: NC_000008.11), ASH1L(SET) (amino acids 19802564, NCBI sequence: NC_000001.11), SETD2(SET) (amino acids 13232564, NCBI sequence: NC_000003.12) and SUV39H1(SET) (amino acids 82412, NCBI sequence: NC_000023.11) were cloned into pGEX-6P-1

However, most of the experimental tests have been conducted in animal models and in vitro experiments, and only a few clinical trials have been conducted

Huynh, U

These reflect a failure of normal follicle or oocyte (ovarian cells that may become eggs) development

The functional annotation analysis identified, as highly enriched cluster related to GTPase activity, cytoskeletal binding, protease inhibitor, catalytic activity, transporter activity, protein-tyrosine kinase activity, and SOD (Fig