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Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

Verdecchia P, Gentile G, Angeli F, Reboldi G

Winkelman JT, Chandrangsu P, Ross W, Gourse RL

The only SLE-specific prevention trial to date is the Study of Anti-Malarials in Incomplete Lupus Erythematosus (SMILE) (61), which was set to determine whether SLE progression can be abrogated by using hydroxychloroquine (HCQ) among patients with a positive ANA test and at least one (but not three or more) additional clinical or laboratory criterion from the 2012 Systemic Lupus Inception Collaborating Clinics (SLICC) classification criteria (181)

Effect of pH on enzyme activity: Figure 5 showed that the velocity of purified rat GST enzyme increased gradually till pH 7.0 which seem to be the optimum pH for the enzyme activity at which a maximum activity was obtained