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While we are not finalizing the Information Transfer PRO-PM in this final rule, we will take these comments into consideration if we propose the measure in the future

Pyruvate is normally supplied to neurons by oligodendrocytes [328], so in addition to providing exogenous pyruvate, promoting metabolic coupling with oligodendrocytes may also be essential for the long-term survival of donor RGCs and should be investigated

J Exp Bot 61:609622 Schopfer P, Liszkai A, Bechtold M, Frahry G, Wagner A (2002) Evidence that hydroxyl radicals mediate auxin-induced extension growth

Minoxidil remains one of the few FDA-approved treatments for AGA, but topical formulations suffer from inconsistent adherence, while oral minoxidil raises concerns around cardiovascular side effects due to peak systemic exposure

However, in the included rodent studies, in 112 out of the 123 cases the ES induced later-life behavior could be mitigated by nutritional supplementations, underscoring the potential for such nutritional strategies