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Without a priori knowledge of what insults were applied, and in which order, simply observing the final histological lesion renders it impossible to infer the underlying sequence of events nor the initial trigger

Frischbutter A (2002) Structure of the Managua graben, Nicaragua, from remote sensing images

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Indirect criteria used to identify paracellular transport include the first-order kinetics in which the amount transported plotted as a function of concentration is linear, lacking the saturation typical of protein-mediated transport mechanisms [24, 30]