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Strengths and limitations One limitation of this study was the small sample size of 12 participants

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Liposomal formulations, reduced glutathione variants, and alternative delivery routes (IV, intramuscular, nebulized) bypass this limitation but require clinical administration

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A significant increase in serum levels of the inflammatory factors IL-1B, TNF-a, and IL-6 was found in hemoglobin-injected mice, whereas the use of inflammatory vesicle inhibitors significantly reduced the levels of hemoglobin-induced inflammatory factors