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Cycle length and breaks AOD-9604 protocols require structured cycling to maintain effectiveness and avoid potential receptor downregulation

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Interestingly, the DNA damage repair protein RRM2, often upregulated in NB to support oncogenicity, was upregulated across all conditions, and phosphorylation at the Ser-80 and Ser-86 sites was significantly downregulated by both combinations ( Supplementary Table S1 ) (4749)