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This animal study was performed in accordance with the following: - UK guidance on the operation of the Animals (Scientific Procedures) Act of 1986 and associated guidelines - EU Directive 2010/63 for the protection of animals used for scientific purposes - The NIH (National Research Council) Guide for the Care and Use of Laboratory Animals The study also complies with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines

The initiator of the pathophysiological process has not been elucidated yet, although acute gastrointestinal infections have been found to initiate the symptoms in a certain group of patients with IBS (post-infectious IBS) (81)

In practice, [hydroquinone] compounded up to 8% is considered to be high and is only recommended for short periods of time, says Lesley Clark-Loeser, MD, a board-certified dermatologist in Davie, Florida

Oral absorption of Vitamin C has limited bioavailability (absorption) and is restricted to a maximum capacity of 200 mg at one time

The ability of gut microbiota to communicate with the brain and in turn induce behavioral changes is emerging as an interesting concept in autism