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In this paper, compounds were described that activate SOS-mediated nucleotide exchange and paradoxically inhibit downstream RAS signalling

Lastly, precision medicine faces high costs and resource constraints, with primary care hospitals often lacking the capacity to acquire necessary equipment and technologies, while personalized nursing increases demands on medical resources (207, 213)

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Alternative methods, such as combining pantoprazole with docetaxel in metastatic castration-resistant prostate cancer, showed that although safe, not every autophagy-targeting strategy achieves the established efficacy benchmarks, highlighting the importance of accurate patient stratification