The Hidden Risks of Vitamin B12 Replacement Therapy Thai Pham January 05, 2025 Vitamin B12 (cobalamin) is a crucial nutrient essential for various bodily functions, including DNA synthesis, red blood cell production, and proper nerve function
Ngoi ra, serum cn kt hp vi Niacinamide thn dc nui dng v bo v t bo da, nga lo ha hiu qu
Erythropoietic porphyrias Congenital erythropoietic porphyria (Gunther disease) Epidemiology Very rare Severe Etiology Autosomal recessive Defective uroporphyrinogen-III synthase Pathophysiology Begins in childhood Bone marrow heme biosynthesis impairment Clinical features Severe photosensitivity leads to light-induced damage burning sensation and redness of the skin with blisters that can develop into ulcers scarring, sometimes severe: Scarring of the cornea (blindness) Loss of fingers Loss of facial features Hemolytic anemia: enzyme dysfunction reduces heme levels and accumulated intermediates disrupt the membrane of erythrocytes and their precursors hypersplenism Bone changes Bone marrow hypertrophy pathologic fractures Acral osteolysis Red stained bones Port-wine colored urine Management No causal therapy Avoid exposure to sunlight Erythropoietic protoporphyria Epidemiology: third most common porphyria Genetics: autosomal dominant (defective ferrochelatase) Clinical features After exposure to sunlight: transient cutaneous findings Protoporphyrin gallstones Rare: chronic hepatic involvement Diagnostics: protoporphyrin in feces and blood Management Protection from sunlight, alpha-MSH Ursodeoxycholic acid, cholestyramine Liver/bone marrow transplantation
Perilipin2 depletion causes lipid droplet enlargement in the ovarian corpus luteum in mice
Such variations can provide evidence of bacterial catalase activity
