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The study confirmed FOXO4-DRI was effective across senescent cells generated by different methods (irradiation, doxorubicin, and replication stress), and documented that pre-treatment with FOXO4-DRI attenuated the dedifferentiation of chondrocytes during in vitro expansion establishing it as a valuable tool for research into senescent cell biology in cartilage and musculoskeletal models

Fresh all-trans retinoic acid (Sigma-Aldrich, Saint Louis, MO) was added to the culture medium at a final concentration of 10 ng/mL

Compliance officers can use the documentation to verify compound specifications meet approved research protocol requirements

An increased number of SGLT2+ TECs has been observed in the kidney of diabetic mice as an adaptive response to hyperglycemia

Studied for wound healing and infection resistance