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Adverse reactions: mild transient diarrhea, polycythemia vera, peripheral vascular thrombosis, transient rash itching, bloating sensation

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Advanced liver disease can alter the levels of B12 binding proteins in the blood, making total serum B12 measurements unreliablelevels may appear normal or even elevated despite functional deficiency

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[8] The honest framing for both is that these are surrogate endpoints body weight, HbA1c, liver fat measured over trial-length horizons