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15 The gene for glutathione peroxidase-4 is expressed in most tissues, including the brain (Gene Expression Atlas, available at Although the GPX4 gene is highly polymorphic, a limited number of studies 16, 17, 18, 19 have been done to investigate genetic variations within the GPX4 gene that could potentially alter the function of the enzyme

Reversely, mTBI, accounting for more than 80% of all TBI patients, is often ignored, as it is generally non-fatal (0.1% lethality) (Theadom et al., 2014)