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Therefore, ER retention observed for STEVORss-Hrs-GFP and STEVORss-HRS C215S -GFP was not due to PI(3)P-specific binding, suggesting another interaction(s) was retaining reporters in the ER, possibly involving unfolded proteins and ER chaperones

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10.1038/s41467-021-20904-2 [DOI] [PMC free article] [PubMed] [Google Scholar] Liu L., He J., Sun G., Huang N., Bian Z., Xu C., et al

Glutamine is an amino acid that exists in two forms: L-glutamine and D-glutamine

394,395 Other signalings can interact with Hippo pathway to promote HCC, such as Notch pathway, EGFR signals, AKT pathway and DDR1 signaling 396,397,398,399 Considering the oncogenic roles of YAP in liver cancer and other disease, it is attractive to develop inhibitors targeting YAP