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Vitamin B12 deficiency can lead to a type of anemia where your red blood cells become too large and dysfunctional (macrocytic anemia)

Some individuals report developing acne after starting B12 supplements or injections, raising questions about this potential side effect

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Leukopenia, macrocytosis, and thrombocytopenia occur in young adults with Down syndrome

Subcutaneous protocols achieve peak plasma levels within 24 hours and maintain therapeutic concentrations for 1216 hours, which supports once-daily dosing