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1,140 (n) 2,815 (n) Wang 35% 0.65 [0.30-1.40] severe case n/a n/a Mendelian - per SD Voloudakis 19% 0.81 [0.72-0.92] cases population-based cohort Tau 2 = 0.04, I 2 = 66.3%, p = 0.0025 Prophylaxis 31% 0.69 [0.55-0.88] 36/1,472 714/20,067 31% lower risk All studies 33% 0.67 [0.51-0.88] 63/1,768 784/20,499 33% lower risk 14 vitamin A COVID-19 studies c19 early .org July 2026 Tau 2 = 0.10, I 2 = 66.1%, p = 0.004 Effect extraction pre-specified (most serious outcome, see appendix) 1 CT: study uses combined treatment Favors vitamin A Favors control Download Image 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Al-Sumiadai 86% 0.14 [0.03-0.61] 2/70 14/70 Improvement, RR [CI] Treatment Control Tau 2 = 0.00, I 2 = 0.0%, p = 0.0083 Early treatment 86% 0.14 [0.03-0.61] 2/70 14/70 86% lower risk Sarohan -282% 3.83 [1.58-9.24] 9/10 4/17 Improvement, RR [CI] Treatment Control Beigm

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In light of these findings, it has been concluded that tobacco smoking is associated with a significantly increased risk of advanced and more severe disease in the form of pulmonary cavitation, positive sputum smear and culture results, and lower conversion rate after treatment initiation (Mahishale et al., 2015)