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The effects of ET on ER stress signaling could be due to improvement of ER homeostasis in some way, or to simple inhibition of UPR signaling

however, it is highly recommended to conduct a patch test prior to regular application of skincare products.[4] Users should discontinue use if they experience any signs of allergic reactions, such as redness, hives, or itchiness.[5] While copper can potentially cause skin irritation or toxicity, in vitro studies suggest that GHK-Cu complexes may have a lower likelihood of inducing these effects.[6] However, it is always recommended to consult a healthcare professional before using any new skincare product

References de Moffarts, B., et al

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doi: 10.1136/archdischild-2017-313880 36 MillerSPFerrieroDM