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doi: 10.1523/JNEUROSCI.4609-07.2008

These observations highlight differences between the immunogenicity of multivalent recombinant protein nanoparticles where immunogens are expressed, purified, and characterized ex vivo prior to delivery of a fixed antigen dose and repRNA, which enables streamlined manufacturing, but the final antigen dose depends on in vivo expression

2022;15:eabj4009