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Restoration of p53 activity through exogenous TP53 gene expression has become both a treatment concept for p53-deficient cancers and an important milestone in gene replacement therapy ( Figure 3 )

For the Ts26GST system, the presence of GSH in its binding site resulted in a small increase in the number of intramolecular hydrogen bonds, as shown in Fig

They play an important role in protein synthesis and are necessary for numerous functions in the body, such as in muscle tissue or the production of enzymes and Hormones

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Practically, this decoupling allows for two separate production streams, enabling independent optimization of folding and post-translational modifications, though it necessitates balancing antigen size with manufacturing complexity and production economics (Park et al., 2023