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In animal studies, LC was found to increase the levels of circulating insulin-like growth factor-1 (IGF-1), which consequently led to the activation of protein kinase B (Akt) and the mammalian target of rapamycin (mTOR) []

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From the cover: correlations between apolipoprotein E 4 gene dose and brain-imaging measurements of regional hypometabolism

A small pilot study designed to evaluate the safety of lipoic acid in 30 people with relapsing or progressive multiple sclerosis found that treatment with 1,200 to 2,400 mg/day of oral lipoic acid for two weeks was generally well tolerated (see Safety) (95)

As long as these ingredients are calorie-free, they should be appropriate for most intermittent fasting frameworks