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two resemble the native dimer, whilst the other two are described as nonnative oligomers predicted to have a propensity towards aberrant interactions, including aggregation (Figure 3).[ 33c , 33d ] These species are clearly of sparse abundance,[ 33c , 33d ] whilst the native barrel monomeric state of disulfidereduced apoSOD1 is the most abundant form

However, the underlying mechanism remains unclear and warrants further investigation

EGCG may prolong neuron survival and protect against retrograde apoptosis, potentially preventing neuronal damage [137]

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