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PGE2 Prostaglandin E2 (PGE2) is a key mediator in the biology of MDSCs, playing a significant role in chronic inflammation and tumor progression

doi: 10.1016/j.micpath.2022.105751 2 ReyesGBetancourtIAndradeBPanchanaFRomanRSorrozaLet al

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however, it is generally unresponsive to treatment

PNMT, the terminal enzyme of the catecholamine biosynthesis pathway, catalyzes the methylation of the neurotransmitter norepinephrine to form epinephrine (Ji et al., 2005)