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Conceptual schematic illustrating the attenuation of circadian rhythm amplitude and phase shifts in aging, with a particular emphasis on nocturnal melatonin decline as a central driver of sleep fragmentation, metabolic dysregulation, and reduced antioxidant capacity ( The figure highlights age-related changes in key physiological variables, including restactivity cycles, core body temperature, hormonal secretion (melatonin and cortisol), suprachiasmatic nucleus (SCN) neuronal activity, and metabolic indicators such as glucose regulation

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Dietary fat and fiber differentially alter intracellular second messengers during tumor development in rat colon

Immunostaining The slices were blocked with PBS containing 2.5%, with PBS containing 2.5% bovine serum albumin (BSA