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Basically these variations are epigenetics the focus in alterations made to the expression of genes, such as when polymorphisms are expressed and down regulations occur (see more about down regulation below)

Cell 165 , 153164 (2016)

PGRN is mainly expressed in neurons and microglia in the brain [97,98,99,100,101], localized to the lysosome, and also secreted into the extracellular space