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The peptide stimulates collagen synthesis by 70% in fibroblast cultures and promotes angiogenesis through VEGF upregulation

Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells

In addition, metallothionein 3 (MT3) can extract Cu 2 + from amyloid- or -synuclein complexes and facilitate its reduction to Cu + , a property attributed to its flexible N-terminal -domain containing a unique threonine insertion at position 5 that distinguishes MT3 from other metallothionein isoforms 195,196